William Christopher Zeise (15 October 1789 – 12 November 1847) was a Danish organic chemist. He is best known for synthesising one of the first organometallic compounds, named Zeise's salt in his honour. He also performed pioneering studies in organosulfur chemistry, discovering the xanthates in 1823.
Early life
William Christopher Zeise was born 15 October 1789 in Slagelse, the son of an apothecary, Frederick Zeise (1754–1836), who was an old friend of physicist Hans Christian Ørsted's father. Zeise attended Slagelse Latin school until he went to Copenhagen in 1805 to take up an apprenticeship under Gottfried Becker as a pharmacy assistant (Apoteksmedhjælper) at the Royal Court Pharmacy. Gottfried Becker, was an accomplished chemist who was employed as extraordinary Professor of Chemistry at the University. However Zeise felt dissatisfied there and returned home complaining of his health after having been there only a few months.
Around this time his interest in science (Natural Philosophy) began to develop. He familiarised himself with the new quantitative chemical theory of Antoine Lavosier; and read widely, including - Nicolai Tychsen's "Apothekerkunst" (Theoretical and practical instructions for Pharmacists, 1804), Gren's Chemistry, Adam Hauch's Principles of Natural Philosophy and Ørsted's papers in Scandinavian Literature and Letters (whose treatise on spontaneous combustion made an especially strong impression on him). At the same time he experimented with a home-made voltaic pile. At 17 years old, he rearranged his father's pharmacy in accordance with the new pharmacopoeia of 1805, which had imposed the antiphlogistic nomenclature. About the same time (summer of 1806) he mentioned in his diary "a most remarkable awakening within me for something higher, for scientific creative work in general, but for Science, chiefly Chemistry, deeply and in particular". How strong an impression this inner experience had made on him, can be established by the fact that he now wanted to return to Copenhagen, not to return to the Court apothecary, but to pursue a path studying chemistry.
Formal academic education
In autumn 1806, he was welcomed into the family home of Ørsted, where he was given a position as an Assistant, helping Ørsted prepare his university lectures. His stay with Ørsted lasted several years and was certainly of the greatest importance for his development. Ørsted himself recounted how he influenced Zeise through conversations and encouraged him when he expressed the desire to take the university entrance examination (Examen artium). Ørsted spoke fondly of Zeise's independent spirit. Zeise became a university student in 1809.
Zeise had at first intended to study medicine, but while attending lectures it became clear that his interests had a broader scientific base; and chemistry remained his favourite subject. He still experimented in Ørsted's Laboratory, but since at that time there was no prospect for a teaching position at the University, he took the pharmacist exam in 1815, later a master's degree (magisterkonferens) and on 21 October 1817 he defended his Doctoral dissertation on 'The effect of Alkalies upon organic substances'. The experimental part of this work he performed in a small laboratory, which in 1816 he had converted from the pharmacy in Slagelse.
As the university had no separate Lecturing Chair in Chemistry and no scientific laboratory, Zeise decided to work and study abroad. In 1818 he managed to get travelling money. Zeise arrived in Göttingen, where he spent four months working in Friedrich Stromeyer's laboratory, one of the few experimental laboratories in Germany at that time. He was trained particularly in analytical chemistry, in which he would become a great master. Zeise next spent nearly a year in Paris. His diary entries reflect how diligent he was, and depict vividly the impression he got of the famous French scientists he came in contact with. In August 1818, while in Paris, Zeise became personally acquainted with the distinguished Swedish chemist Jöns Jacob Berzelius. Berzelius received the young Danish chemist with great benevolence, expressing his admiration for Zeise's Doctoral thesis. They continued a respectful friendship thereafter, despite Zeise being ten years younger than Berzelius.