Conceição Bettencourt works in the field of neuro-epigenetics. She studies the involvement of disrupted molecular pathways and çãDNA methylation in neurodegenerative diseases using human post-mortem brain tissue. She is research fellow of the Alzheimer's Research UK and co-leads the Genetics and Omics Working Group of the international Deep Dementia Phenotyping (DEMON) network.
Education and career
Bettencourt studied Biology and Human Genetics at the University of the Azores, where she conducted her PhD on "Machado-Joseph disease: from genetic variability to clinical heterogeneity". She then trained as a postdoc in Spain and the Netherlands.
Significant publications
Murthy, Megha; Cheng, Yun Yung; Holton, Janice L.; Bettencourt, Conceição (December 2021). "Neurodegenerative movement disorders: An epigenetics perspective and promise for the future". Neuropathology and Applied Neurobiology. 47 (7): 897–909. Bettencourt, Conceição; Foti, Sandrine C.; Miki, Yasuo; Botia, Juan; Chatterjee, Aparajita; Warner, Thomas T.; Revesz, Tamas; Lashley, Tammaryn; Balazs, Robert; Viré, Emmanuelle; Holton, Janice L. (January 2020). "White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy". Acta Neuropathologica. 139 (1): 135–156. Bettencourt, Conceição; Hensman-Moss, Davina; Flower, Michael; Wiethoff, Sarah; Brice, Alexis; Goizet, Cyril; Stevanin, Giovanni; Koutsis, Georgios; Karadima, Georgia; Panas, Marios; Yescas-Gómez, Petra; García-Velázquez, Lizbeth Esmeralda; Alonso-Vilatela, María Elisa; Lima, Manuela; Raposo, Mafalda; Traynor, Bryan; Sweeney, Mary; Wood, Nicholas; Giunti, Paola; Durr, Alexandra; Holmans, Peter; Houlden, Henry; Tabrizi, Sarah J.; Jones, Lesley (June 2016). "DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases: DNA Repair Pathways Modify polyQ Disease Onset". Annals of Neurology. 79 (6): 983–990. Bettencourt, Conceição; Forabosco, Paola; Wiethoff, Sarah; Heidari, Moones; Johnstone, Daniel M.; Botía, Juan A.; Collingwood, Joanna F.; Hardy, John; Milward, Elizabeth A.; Ryten, Mina; Houlden, Henry (March 2016). "Gene co-expression networks shed light into diseases of brain iron accumulation". Neurobiology of Disease. 87: 59–68. Bettencourt, Conceição; Ryten, Mina; Forabosco, Paola; Schorge, Stephanie; Hersheson, Joshua; Hardy, John; Houlden, Henry (1 July 2014). "Insights From Cerebellar Transcriptomic Analysis Into the Pathogenesis of Ataxia". JAMA Neurology. 71 (7): 831.
References
Living people
Place of birth missing (living people) Year of birth missing (living people) Nationality missing University of the Azores alumni Women biologists