The 2022 San Marino Open was a professional tennis tournament played on clay courts. The 29th edition of the tournament, which was part of the 2022 ATP Challenger Tour, took place in City of San Marino, San Marino between 8 and 14 August 2022.
Singles main-draw entrants
Seeds
1 Rankings are as of 1 August 2022.

Other entrants
The following players received wildcards into the singles main draw: Mattia Bellucci Flavio Cobolli Ernests Gulbis

The following players received entry into the singles main draw as alternates: Ivan Gakhov Maxime Janvier Filip Cristian Jianu

The following players received entry from the qualifying draw: Viktor Durasovic Francesco Forti Lukas Neumayer Oleg Prihodko Valentin Vacherot Alexander Weis
Champions
Singles
Pavel Kotov def. Matteo Arnaldi 7–6(7–5), 6–4.
Doubles
Marco Bortolotti / Sergio Martos Gornés def. Ivan Sabanov / Matej Sabanov 6–4, 6–4.





