Mirco Spagnolo (born 2 January 2001) is an Italian rugby union player. His usual position is as a Prop and he currently plays for Benetton in United Rugby Championship.
After two seasons with Petrarca Padova, Spagnolo signed for Benetton Rugby in June 2023 ahead of the 2023–24 United Rugby Championship. He made his debut in Round 1 of the 2023–24 season against the .
In 2021 Spagnolo was named in Italy U20s squad for annual Six Nations Under 20s Championship. On 26 May 2022, for the match against Netherlands, he was named in the 30-man Emerging Italy squad for the 2022 July rugby union tests and in Italy A squad for the South African tour in the 2022 mid-year rugby union tests against Namibia and Currie Cup XV team.