The scene of contest in the wars between Rome and Persia had been usually either Mesopotamia or Armenia. On rare occasions only had the traditional policy been departed from, and attempts made to penetrate into the richer parts of the Roman East, and to inflict serious injury on the empire by carrying fire and sword into peaceful and settled provinces. Kobad, however, had in his later years ventured to introduce a new system, and had sent troops across the Euphrates into Syria in the hope of ravaging that fertile region and capturing its wealthy metropolis, Antioch. This example Chosroes now determined to follow. Crossing the great stream in the lower portion of its course, he led his troops up its right bank, past Circesium, Zenobia, and Callinicus, to Suron, a Roman town on the west side of the river. As this small place ventured to resist him, Chosroes, bent upon terrifying the other towns into submission, resolved to take a signal revenge. Though the garrison, after losing their commandant, made overtures for a surrender, he insisted on entering forcibly at one of the gates, and then, upon the strength of this violent entrance, proceeded to treat the city as one taken by storm, pillaged the houses, massacred a large portion of the inhabitants, enslaved the others, and in conclusion set the place on fire and burned it to the ground. It was perhaps in a fit of remorse, though possibly only under the influence of greed, that shortly afterwards he allowed the neighboring bishop of Sergiopolis to ransom these unfortunate captives, twelve thousand, in number, for the modest sum of two hundred pounds of gold.
From Suron the invading army advanced to Hierapolis, without encountering the enemy, who did not dare to make any resistance in the open field, but sought the protection of walls and strongholds. The defences of Hierapolis were in tolerable order; its garrison was fairly strong; and the Great King therefore prudently resolved to allow the citizens to ransom themselves and their city at a moderate price. Two thousand pounds of silver was the amount fixed upon; and this sum was paid without any complaint by the Hierapolites. Plunder, not conquest, was already distinctly set before the invader's mind as his aim; and it is said that he even offered at this period to evacuate the Roman territory altogether upon receiving a thousand pounds of gold. But the Romans were not yet brought so low as to purchase a peace; it was thought that Antioch and the other important towns might successfully defy the Persian arms, and hoped that Justinian would soon send into the field an army strong enough to cope with that of his adversary. The terms, therefore, which Chosroes offered by the mouth of Megas, bishop of Berhcea, were rejected; the Antiochenes were exhorted to remain firm; Ephraim, the bishop, was denounced to the authorities for counselling submission; and it was determined to make no pacific arrangement, but to allow Chosroes to do his worst. The Persian, on his side, was not slack or remiss. No sooner had he received the ransom of Hierapolis than he advanced upon Berhoea (now Aleppo), which he reached in four days. Observing that the defences were weak, he here demanded twice the ransom that he had accepted from the Hierapolites, and was only induced to forego the claim by the tears and entreaties of the good bishop, who convinced him at length that the Berhoeans could not pay so large a sum, and induced him to accept the half of it. A few more days' march brought him from Aleppo to the outskirts of Antioch; and after an interval of nearly three centuries the "Queen of the East," the richest and most magnificent of Oriental cities, was once more invested by Persian troops and threatened by a Sassanian monarch.