The First National Bank is a historic commercial building at 109 East University Street in Siloam Springs, Arkansas. It is a two-story brick building, trimmed in stone. Its ground floor is recessed in an arcade supported by square posts, and is separated from the second floor by a stone belt course. The upper floor windows have round stone arches, with two narrow bays projecting slightly. The cornice has corbelled brickwork, and is topped in a few places by stone caps. The building is Siloam Springs' only significant example of Romanesque Revival architecture.
The building was listed on the National Register of Historic Places in 1988.