This is a list of notable alumni of Mfantsipim School.
Politics
Kobina Sekyi - President, Aborigines' Rights Protection Society (ARPS), lawyer, writer, author of The Blinkards Kofi Abrefa Busia - Prime Minister of Ghana William Ofori Atta - Member of the Big Six Joseph W.S. de-Graft Johnson - Vice President of Ghana (1979–1981) John C. de-Graft Johnson - Ambassador in The Hague (1967-1970) Kow Nkensen Arkaah - Vice President of Ghana (1992–1996) Kwesi Amissah-Arthur - Vice President of Ghana (2012-2017) Albert Adu Boahen - First Presidential Candidate of the New Patriotic Party (NPP). Flagbearer in the 1992 general election Joseph Ephraim Casely-Hayford - Lawyer and politician and member of Fante Confederacy and Aborigines' Rights Protection Society Papa Owusu-Ankomah - Former MP for Sekondi (7 January 1997 – 6 January 2017), and Minister of State (2001–2008). Samuel Atta Mills - Member of parliament for the Komenda-Edina-Eguafo-Abirem Constituency (2017–) Kwabena Agyapong - Politician, Former General Secretary of the NPP Boakye Agyarko - Former Minister for Energy, Ghana George Emmanuel Kwesi Aikins - Former Attorney General of Ghana Kwabena Kwakye Anti - Minister in the second republic Joe Appiah - politician Albert Bosomtwi-Sam - MP for Sekondi (1992 to 1996) Francis Yao Asare - Minister in the first republic Kwaku Boateng - minister in the first republic T. D. Brodie-Mends - minister in the second republic Archie Casely-Hayford - lawyer and politician Isaac Chinebuah - academic and politician Alexander Apeatu Aboagye da Costa - deputy minister in the Busia government Alfred Jonas Dowuona-Hammond - Minister in the first republic Kwaku Baah - Deputy Minister in the Busia government Kwamena Bartels - Minister of state in the Kufuor government Justice Akuamoa Boateng - deputy minister in the Busia government Kwamena Duncan - Central Regional Minister, Akufo-Addo government John Kofi Fynn - Deputy Minister in the Busia government Ashford Emmanuel Inkumsah - Minister in the first republic J. Kwesi Lamptey - minister in the second republic Kofi Asante Ofori-Atta - politician, former Speaker of the Parliament of Ghana J. V. L. Phillips - Minister in the NLC regime Augustus Obuadum Tanoh - Founding member of the National Democratic Congress, founder of the National Reform Party and presidential candidate in the 2000 Ghanaian general election Emmanuel Gyekye Tanoh - Minister of state in the PNDC regime Samuel Atta Mills - Member of Parliament for Komenda Edina Eguafo Abrem from 2016 to present
Traditional Rulers
Nana Kobina Nketsia V - Paramount Chief of Essikado Traditional Area
Ghanaian MPs
Joe Ghartey - lawyer, MP for Ketan-Essikado, Minister of Railways
Edwin Nii Lante Vanderpuye - journalist, MP for Odododiodio
Anthony Seibu Alec Abban - MP for Ajumako-Asikuma and later Ajumako during the first republic Swinthin Maxwell Arko - MP for Agona Nsaba during the first republic Dr. Henry Satorius Bannerman - MP for Ashiedu Keteke during the second republic Kwabena Okyere Darko-Mensah - MP for Takoradi, Deputy minister Kobina Hagan - MP for Denkyira during the first republic James Gyakye Quayson - MP for Assin North (Elected in 2020 and re-elected in 2023 through a bye-election) Samuel Atta Mills - Member of Parliament for Komenda Edina Eguafo Abrem KEEA
Diplomats
Kofi Annan - former UN Secretary General
Mohamed Ibn Chambas - former MP and diplomat
J. L. S. Abbey - former diplomat
James Aggrey-Orleans - former Ghanaian envoy to the UK
Francis Lodowic Bartels - former diplomat
Ebenezer Moses Debrah - former diplomat
Patrick R. D. Hayford - former diplomat, Ghana's Ambassador to South Africa (1997–1999) Alex Quaison-Sackey - first black president of the UN General Assembly Nana Effah-Apenteng - former permanent representative of Ghana to the United Nations William George Mensah Brandful - retired diplomat Papa Owusu-Ankomah, diplomat, 2017 to date Miguel Augustus Francisco Ribeiro - former diplomat Eric Kwamina Otoo, former diplomat Yaw Bamful Turkson, career diplomat and Ambassador(1957-1988)
Public service
John Henry Martey Newman - Chief of staff of John Evans Atta Mills administration Benjamin Asante - CEO, Ghana National Gas Company