Gentlemen, I will now in a few words give you the allegations upon the one side and on the other. On the part of the prosecution it is alleged that the deceased, John Parsons Cook, was first tampered with by antimony, that he was then killed by strychnia, and that his symptoms were the symptoms of poison by strychnia. It is then alleged that the prisoner at the bar had a motive for making away with him; that he had an opportunity of administering the poison; that suspicion fell upon no one else; and that on two days, when the poison was supposed to have been administered, he actually purchased strychnia, the poison employed; and that, as they allege, his conduct before that transaction, before the deed, while it was going on, and afterwards, was that of a guilty, and not of an innocent, man. On the other side it is contended (and you are to say whether or not truly contended) that the prisoner at the bar was really the victim of prejudice; that he had no interest in the death of the deceased; and, on the contrary, that the death of the deceased was to his prejudice; further, that Cook did not die from poison by strychnia, but from natural disease; that his symptoms were those of natural disease, and not of poison by strychnia; and, further, it is contended that no part of the evidence which has been given shows anything which is at all consistent with the guilt of the prisoner. Gentlemen, it is for you to determine between the allegations on the one side and the other according to the evidence. A most anxious task is imposed upon you, knowing that the life of the prisoner is at stake; and, if you find him guilty, he must expiate his crime by an ignominious death. It is of the last importance that you should be convinced of his innocence or his guilt; and, if you are not convinced of his guilt, you will rescue him from the fate with which he is threatened. On the other hand, when you have heard the statements which were given in evidence--if you are satisfied of his guilt--it will be your duty to return a verdict of guilty; for if the poisoner were to escape with impunity, there would be no safety for mankind, and society would fall to pieces. Gentlemen, the burthen of proving the guilt rests on the prosecution; and unless that is fully sustained, and you are not convinced upon the evidence that he is guilty, then it will be your duty to acquit the prisoner; but in a case of this kind you cannot expect that witnesses should be called to state that they saw the deadly poison administered by the prisoner or mixed up by the prisoner openly before them. Circumstantial evidence as to that is all that can be reasonably expected; and if there are a series of circumstances leading to the conclusion of guilt, then, gentlemen, a verdict of guilty may satisfactorily be pronounced. With respect to the alleged motive, it is of great importance to see whether there was a motive for committing such a crime, or whether there was not, or whether there is an improbability of its having been committed so strong as not to be overpowered by positive evidence. But, gentlemen, if there be any motive which can be assigned, I am bound to tell you that the adequacy of that motive is of little importance. We know from the experience of criminal Courts that atrocious crimes of this sort have been committed from very slight motives, not merely from malice and revenge, but to gain a small pecuniary advantage and to drive off for a time pressing difficulties. It seems to me, gentlemen, you will have to consider well whether the symptoms of Cook’s death are consistent with a poisoning by strychnia. If they are not, if you believe that death arose from natural causes, the prisoner is at once entitled to a verdict of not guilty at your hands; but if those symptoms are consistent with a poisoning by strychnia, then you will have another and an important question to consider, whether the evidence which has been adduced is sufficient to convince you that it was a death by strychnia, and by strychnia which the prisoner administered. In cases of the sort the evidence has often been divided into medical and moral evidence, the medical being that of the scientific men, and the moral the circumstantial facts which are calculated to prove the truth of the charge against the party accused. Gentlemen, they cannot be finally separated in the minds of the jury, because it is by combination of the two species of evidence that their verdict ought to be found.