Mountain Shoals Plantation, also known as the James Nesbitt House, is a historic plantation house located at Enoree, Spartanburg County, South Carolina. It was built by 1837, and is a two-story, vernacular Federal style frame residence. It sits on a raised brick basement stuccoed to resemble granite and features a full-width, one-story, front porch. Also located on the property is a contributing well house and a one-story log cabin (c. 1815).
It was listed on the National Register of Historic Places in 1979.