The Samruddhi Mahamarg or Nagpur-Mumbai Expressway (officially known as Hindu Hrudaysamrat Balasaheb Thackeray Maharashtra Samruddhi Mahamarg) and Maharashtra Expressway-2 (ME-2), is a partially opened 6-lane wide (expandable to 8), 701-km long access-controlled expressway in Maharashtra, India. It is amongst the country's longest greenfield road projects, which will connect the two capital cities of the state, its capital, Mumbai, and its third-largest and vice-capital city, Nagpur. The project is being led by the state infrastructure arm Maharashtra State Road Development Corporation (MSRDC), and is designed under the Engineering, Procurement and Construction (EPC) model.

With the route alignment connecting Shivmadka village in Nagpur district to Amane village in Thane district, the expressway is capable of providing an enhanced connectivity to the Marathwada and Vidarbha regions. The total project cost, including the land acquisition cost, is around . The Government of Maharashtra believes that the expressway will become a prosperity corridor for the overall socio-economic growth of the state.

Mumbai–Nagpur Expressway

Route alignment

The Mumbai–Nagpur Expressway will travel through 10 key districts directly and 14 districts indirectly via feeder roads, 24 talukas, and 392 villages. The 10 main districts are Nagpur, Wardha, Amravati, Washim, Buldhana, Jalna, Aurangabad, Nashik, Ambikanagar and Thane. The other 14 districts include Chandrapur, Bhandara, Gondia, Gadchiroli, Yavatmal, Akola, Hingoli, Parbhani, Nanded, Beed, Dhule, Jalgaon, Palghar and Raigad. Yavatmal City is going to Connect with Four Lane road to Samruddhi Expressway and Amravati too.Four Lane Road will be construct between Yavatmal City to Badnera.

Mumbai–Nagpur Expressway

Cities and towns

Below are the lists of cities/towns through which the Mumbai–Nagpur Expressway will connect: Center of Bhiwandi North of Kalyan South of Shahapur South of Igatpuri (Nashik) South of Sinnar South of Kopargaon North of Shirdi South of Vaijapur North of Aurangabad Caves North of Shendra North of Jalna North of Sindkhed Raja North of Mehkar North of Malegaon Jahangir North of Karanja Lad South of Dhamangaon North of Pulgaon North of Wardha South of Seloo West of Butibori Power Plant South of MIHAN SEZ (Nagpur)

Mumbai–Nagpur Expressway

Enhanced connectivity

To create a fast logistics gateway for national and international trade, the expressway will connect the country's largest container port JNPT in Mumbai to Mihan in Nagpur. The expressway will allow access to several industrial and economic corridors through 24 interchanges at strategic locations. It will widely connect the Delhi-Mumbai Industrial Corridor, Bengaluru-Chennai Economic Corridor, Western Dedicated Freight Corridor, Eastern Dedicated Freight Corridor, Chennai-Vizag Economic Corridor and Golden Quadrilateral. Apart from JNPT other seaports including Kandla MBPT, Mormugao, New Mangalore, Kochi, Chennai, Visakhapatnam and Ennore will also have indirect connectivity.