The following is a timeline of the Syrian civil war for 2022. Information about aggregated casualty counts is found in Casualties of the Syrian civil war.

January

On 1 January, the Syrian Observatory for Human Rights (SOHR), a monitor based in the United Kingdom, reported that its activists had documented several Russian and government airstrikes in Northwest Syria. They said three civilians were killed in a Russian airstrike on a building north of Jisr al-Shughur, west of Idlib in Northwestern Syria, in an area controlled by rebels, as part of the on-going Russian involvement in the Syrian civil war, and that the Al-Fath Al-Mubin rebel faction counterattacked with rocket fire on government positions in Jorin area of Hama countryside and around Maarat al-Numan in the southern Idlib countryside.

Timeline of the Syrian civil war (2022)

On the same day in territories controlled by the government and the Kurdish-led Syrian Democratic Forces (SDF) in Northeastern Syria, according to SOHR, at least 10 Russian airstrikes targeted positions of Islamic State (ISIL) cells in the Al-Rusafa desert, north-east of Raqqa city. A Syrian government military convoy comprising at least 100 soldiers of the Liwa al-Quds militia and the Syrian Army's 5th Corps, reportedly under orders from Russia and accompanied by Russian helicopters, arrived in Palmyra from Deir ez-Zor with tanks and armored vehicles to combat ISIS cells in the Palmyra desert. SOHR said these operations were part of a new Russian large-scale military campaign to respond to increased ISIL activity.

Timeline of the Syrian civil war (2022)

On 2 January, as part of this increased ISIL activity in Northeast Syria, five Syrian government soldiers were killed and 20 others were injured after ISIL operatives launched a rocket and artillery attack on a government military vehicle in the eastern part of the Syrian Desert.

Timeline of the Syrian civil war (2022)

Also on 2 January, according to SOHR, Turkish forces shelled Fatima village in the Ain Issa countryside in the Tell Abyad District of Raqqa Governorate, an area controlled by the Kurdish-led Autonomous Administration of North and East Syria (AANES), injuring an SDF fighter who died three days later.

On 4 January, according to SOHR, a commander of Ahrar al-Sham and his nephew were killed on a bridge near Jindires in the Afrin District of the Aleppo Governorate in Northwestern Syria, in territory controlled by the Turkey-backed Syrian National Army (SNA), by other Ahrar al-Sham members after their car was stopped at a checkpoint, which led to a gunfight between the militants.

On 5 January, as part of an uptick in the on-going 2019-2022 Persian Gulf crisis, the U.S "Green Village" military base, near the town of Mayadin in the Deir ez-Zor Governorate was attacked by Iranian-backed militias, who fired eight rockets at the military base (which houses SDF and Coalition fighters), causing minor damage. Several suspected launch sites were destroyed by U.S forces shortly after the attack. The attack came shortly after the 2nd anniversary of the U.S assassination of an Iranian General in 2020.

The same day, continuing on-going Israeli airstrikes on Iranian and government targets in Southern Syria, Israeli tanks fired at Syrian army positions in the town of Quneitra near the Golan Heights, in the Daraa Governorate, setting fire to a building.

On the same day, as part of the upsurge since 2019 of the on-going Daraa insurgency in Southern Syria, a Syrian soldier of the 4th Division, a member of a "reconciled" rebel militia (i.e. an opposition fighting group absorbed into the government forces) accused of drug trafficking, was shot dead by gunmen in the village of Saham al-Jawlan in the western Daraa countryside, according to SOHR.

On 6 January, in the continuing Russian-ISIL conflict in Northeastern Syria, SOHR reported that three Syrian soldiers were killed and 2 others were wounded in an ISIS ambush in the Al-Rusafa desert northeast of Raqqa city. In response, the Russian airforce launched several airstrikes on ISIS positions, causing an unknown number of casualties.

On 8 January, three Turkish soldiers were killed after an IED was detonated under their vehicle on the Syrian-Turkish border near the town of Tell Abyad in Raqqa Governorate. Turkish officials announced the IED was "planted by terrorists", likely referring to Kurdish People's Defense Units (YPG) forces.

On 10 January, as the Daraa insurgency intensified, SOHR reported that two soldiers of the Syrian Army's Military Security were shot dead by gunmen in the outskirts of Al-Sanamayn city, in Daraa Governorate in southern Syria. On the same day in the Northeast, ISIL claimed to have abducted and then executed a "spy" who was working with SDF forces in the town of Hajin.