The 1949 All-Big Six Conference football team consists of American football players chosen by various organizations for All-Big Six Conference teams for the 1949 college football season. The selectors for the 1949 season included the Associated Press (AP) and United Press (UP). Players who were the consensus first-team selection of both the AP and UP are shown in bold.
All-Big Seven selections
Backs
Darrell Royal, Oklahoma (AP-1; UP-1 [QB]) (College Football Hall of Fame) George Thomas, Oklahoma (AP-1; UP-1) Dick Braznell, Missouri (AP-1; UP-1) Bill Weeks, Iowa State (AP-1) John Glorioso, Missouri (UP-1)
Ends
Jim Owens, Oklahoma (AP-1; UP-1) Jim Doran, Iowa State (AP-1; UP-1)
Tackles
Wade Walker, Oklahoma (AP-1; UP-1) Charles Toogood, Nebraska (AP-1; UP-1)
Guards
Stanley West, Oklahoma (AP-1; UP-1) Dick Tomlinson, Kansas (AP-1; UP-1)
Centers
Tom Novak, Nebraska (AP-1; UP-1)