The 2021–22 Mid-American Conference women's basketball season began with practices in October 2021, followed by the start of the 2021–22 NCAA Division I women's basketball season in November. Conference play began in January 2022 and concluded in March 2022. Toledo won the MAC regular season championship with a conference record of 19–1.
Second seeded Buffalo won the MAC tournament with a 79–75 win over . With the automatic bid, Buffalo was the only MAC school to qualify for the NCAA tournament where they lost to Tennessee in the first round. Toledo, Akron, Ball State, Kent State, and Ohio all accepted bids to the WNIT. Bowling Green accepted a bid to the WBI.
Preseason Awards
The preseason coaches' poll and league awards were announced by the league office on November 3, 2021.
Preseason women's basketball coaches poll
(First place votes in parentheses) Ohio (4) 132 (3) 124 Buffalo (3) 123 102 (1) 83 80 79 67 (1) 65 31 27 23
MAC Tournament Champion: Buffalo (5), Ohio (3), BGSU (2), Ball State (1), EMU (1)