The 2021 Potchefstroom Open was a professional tennis tournament played on hard courts. It was the second edition of the tournament which was part of the 2021 ATP Challenger Tour. It took place in Potchefstroom, South Africa between 8 and 14 February 2021.
Singles main-draw entrants
Seeds
1 Rankings are as of 1 February 2021.
Other entrants
The following players received wildcards into the singles main draw: Robbie Arends Vaughn Hunter Khololwam Montsi
The following players received entry into the singles main draw using protected rankings: Jenson Brooksby Julien Cagnina
The following players received entry from the qualifying draw: Mirza Bašić Liam Broady Nick Chappell Ryan Peniston
Champions
Singles
Benjamin Bonzi def. Liam Broady 7–5, 6–4.
Doubles
Marc-Andrea Hüsler / Zdeněk Kolář def. Peter Polansky / Brayden Schnur 6–4, 2–6, [10–4].